WHAT IS PGT TEST?

Preimplantation genetic testing (PGT) is a test that collects a small number of cells from an embryo to check for chromosomal (nst) abnormalities in the embryo. There are three types of test: PGT-A, PGT -M and PGT-SR.

The most common of these is PGT-A, which is a method of transplantation after confirmation of chromosome number. Because it helps increase implantation and pregnancy rates, and reduces miscarriage rates, this method is increasingly used in cases of multiple miscarriages in the past, resulting in repeated IVF failures and the number of miscarriages. The number of elderly infertile patients is increasing with the increase in late marriage.

Diagnosis of 46 chromosomes through NGS testing

At Cha Bundang Hospital, some cells are removed from blastocyst stage cells and NGS technology (Next Generation Sequencing) is applied to diagnose 46 chromosomes. It can be applied when parents have abnormalities in chromosome structure, when abnormalities in the number of chromosomes are suspected, during pregnancy the fetus has abnormalities in chromosomes in older women, recurrent spontaneous abortions, Repeated implantation failure and oligospermia.

Chromosomes in humans represent 2 cells linked together into a set (?), the total number of normal cells is 46, including a total of 22 homologous chromosomes and a pair of sex chromosomes (XX, XY). . (2n=46) The numerical abnormality of chromosome 2n means that the total number of chromosomes in the embryo is not 46.

PGT testing to ensure that the number of chromosomes is accurate

Except for the sex chromosomes, the chromosomes of a normal embryo are numbered in pairs from 1 to 22. In most cases, if there are chromosomal abnormalities, it is very difficult to conceive. The goal of PGT is to check whether the number of chromosomes is accurate and to identify common diseases caused by chromosomal abnormalities, including Down syndrome, Patau syndrome, and Edwards syndrome.

In the case of abnormal embryos, the implantation rate is very low, and there is very little evidence of outcomes for children born from abnormal embryos; therefore, implantation is not recommended.

On the other hand, since the blastocyst is an embryo at a very early stage, the number of chromosomes among the cells may be mixed between normal and abnormal. This condition of mixing normal and abnormal chromosomes is called “mosaicism,” in which case, after consulting with the treating physician, a decision is made regarding whether to implant the mosaic embryo alongside the normal embryos.

QUESTIONS AND ANSWERS ABOUT INFERTILITY TREATMENT – OVULATION INJECTION

16/06/2024

Is it possible to be pregnant if there are two lines after ovulation injection? The injection causes the follicle to rupture, so you may see two lines on a pregnancy test within 14 days after the injection. If you still see two lines after 14 days, you may be pregnant. 2. What […]

QUESTIONS AND ANSWERS ABOUT IVF – IN VITRO FERTILATION

10/06/2024

When should I go to the hospital to check my ovulation date? If you are checking your ovulation date during a natural cycle without inducing multiple ovulations (with a 28–30 day menstrual cycle), you can visit the hospital for testing about 11–12 days after your period starts. When should I go to the hospital […]

NUTRITIONAL SUPPLEMENT FOR INFERTILITY

05/06/2024

The human body absorbs nutrients through food. A balanced diet can provide us with most of the essential nutrients necessary for life. Nutrient absorption from food is very important and should not be replaced by medication. However, there are some nutrients that cannot be absorbed through food and need to be supplemented externally. For couples […]

ALL ABOUT CERVICAL CANCER SCREENING

31/05/2024

What to Do When Faced with “Reactive Cellular Changes” and “Atypical Squamous Cells”? The purpose of this test is to detect cervical cancer or its precursors, so changes in reactive cells can be considered normal from this perspective. However, atypical squamous cells represent a completely different issue. Their diversity can even lead to precancerous stages […]

HOW SHOULD I EAT AFTER GASTRIC REMOVAL SURGERY?

23/05/2024

Eat many small meals, eat slowly and often To help the stomach recover and prevent dumping syndrome, meals should be divided into 6 – 8 portions per day, chewed thoroughly (more than 20 times). Eat slowly, step by step – Start with 1/3 cup of rice and gradually increase the amount eaten little by […]

SYMPTOMS AFTER GASTRIC REMOVAL SURGERY

22/05/2024

The stomach functions as a temporary storage and digestion organ for food. After gastric bypass surgery, both of these functions may be compromised, and patients may experience the following symptoms: ► Weight loss: Within approximately six months post-surgery, patients typically lose between 10-15% of their body weight, and in some cases, up to 20%. […]

ANSWERS TO QUESTIONS ABOUT OBESITY TREATMENT

17/05/2024

When to Use Medication or Injections for Obesity Treatment Obesity can shorten human lifespan in the long term and requires treatment. Medications for obesity can be prescribed if the body mass index (BMI) is 30 or higher in the absence of comorbidities, or 27 or higher if there are additional health issues. It is advisable […]

POSTPARTUM AND NEWBORN CARE AT CHA HOSPITAL

14/05/2024

The Postpartum Care Center at CHA Bundang Women’s Hospital is located within the same building as the Obstetrics and Gynecology Department, the Pediatrics Department, and the Pediatric Emergency Medical Center, allowing for quick responses to emergency situations for mothers and babies. Room type of the center Bundang CHA Women’s Hospital’s postpartum care center is […]

WHAT IS PGT TEST? - liveagain